Mooren's ulcer.

نویسندگان

  • M E Zegans
  • M Srinivasan
چکیده

Disease Course Pain is almost always associated with the onset of Mooren’s ulcer. One or both eyes may be involved at either the same time or one following the other. Approximately two thirds of cases affect one eye only. Mooren’s ulcer is more common in men than women. The eye is usually red and the vision may or may not be reduced. Damage begins at the edge of the cornea (near the junction between the white part of the eye and the clear front portion, or cornea) and may progress to involve the central cornea. A serious complication of Mooren’s ulcer is formation of a perforation or hole, in the cornea. If this occurs there is a risk of damage to the sensitive internal structures of the eye and development of a destructive infection inside the eye. In addition, if the center of the cornea is scarred or distorted, light may not be properly focused on the retina and vision will be reduced.

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منابع مشابه

Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer

PURPOSE To investigate the clinical characteristics of Mooren's ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren's ulcer. METHODS We reviewed the medical records of 95 patients (100 eyes) diagnosed with Mooren's ulcer from May 2005 to December 2014. The patients were classified into recurrent and nonrecurrent groups and followed up for 18 mon...

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Corneoscleral graft in Mooren's ulcer: a case report

INTRODUCTION Mooren's ulcer is a rare disorder of unknown etiology that is refractory to treatment. It can affect not just the cornea but also the scleral tissue and can involve both eyes. CASE PRESENTATION We report a case of a 74-year-old man with a history of bilateral and malignant Mooren's ulcer. The patient had undergone an exenteratio bulbi of the left eye because of the perforation of...

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HLA-DR17 and Mooren's ulcer in South India.

OBJECTIVE To investigate the association between Mooren's ulcer and human leucocyte antigen (HLA) type DR17(3) in patients from the Tamil Nadu State of South India. METHODS Blood samples from 38 patients with Mooren's ulcer and 45 age- and sex-matched controls were obtained prospectively. HLA-DR and HLA-DQ typing was performed by PCR using sequence-specific primers. RESULTS Fifteen (40%) of...

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The Involvement of Multipotential Progenitor Cells in Mooren's Ulcer

The aim of this study was to assess the involvement of multipotential progenitor cells in the pathogenesis of Mooren's ulcer using immunohistochemical staining techniques. Tissue specimens were collected from 3 Mooren's ulcer patients who underwent lamellar keratectomy. Immunohistochemical staining patterns were analyzed using antibodies: CD34, c-kit, STRO-1, CD45RO, VEGF and a-SMA. Strong posi...

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HLA and Mooren's ulceration.

BACKGROUND Mooren's ulcer is a progressive intractable destructive peripheral ulceration of the cornea, probably of autoimmune aetiology. The disease is rare in the northern hemisphere but is more common in southern and central Africa and the Indian subcontinent. Although rare, its predominance in certain racial groups and their second generation migrants worldwide indicates a genetic as well a...

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Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren’s ulcer

BACKGROUND Mooren's ulcer is a severe ulcerative inflammation of the cornea. The exact pathogenesis remains unclear. Therefore many therapies of Mooren's ulcer are recommended in literature. To shed more light on the ongoing question of optimal treatment of severe progressive Mooren's ulcer, we here report on a retrospective case series of patients treated with systemic immunosuppressive therap...

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عنوان ژورنال:
  • International ophthalmology clinics

دوره 38 4  شماره 

صفحات  -

تاریخ انتشار 1998